Evaluation of cardiovascular autonomic modulation during isometric wall squat in subjects after myocardial or percutaneous revascularization
DOI:
https://doi.org/10.47197/retos.v69.115349Keywords:
Acute coronary syndrome, autonomic nervous system, isometric exercise, myocardial revascularizationAbstract
Introduction: Cardiovascular autonomic modulation reflects the interaction between the autonomic nervous system and the cardiovascular system. It can be assessed through heart rate variability (HRV), a key marker of cardiovascular health; low HRV indicates reduced adaptive capacity.
Objective: To compare HRV at rest and during exercise in people post myocardial revascularization (RVM) and percutaneous transluminal coronary angioplasty (PTCA).
Method: An analytical cross-sectional study was conducted with 37 participants. HRV was assessed using electrocardiogram recordings first in the supine position for 10 minutes, then during a 2-minute wall sit isometric exercise (SIP).
Results: The average age was 64.6±9.3 years. The RR interval significantly decreased (p<0.001) during the SIP, indicating increased sympathetic activation. However, no statistically significant differences were found in LF (low frequency), HF (high frequency), or the LF/HF ratio between rest and exercise.
Discussion: A reduction in HRV during the SIP was observed, consistent with Brockmann et al. (2023), who reported a progressive decline in HRV with increased exercise intensity on a treadmill. Unlike previous studies that used handgrip tests (Leite et al., 2010), this study employed a 2-minute SIP protocol, demonstrating its potential as a tool for assessing autonomic modulation during static exertion in cardiovascular populations.
Conclusion: The wall sit isometric exercise appears to be a safe, accessible, and valuable method for evaluating autonomic modulation during exercise in people with post-revascularization procedures.
References
Ardell, Jeffrey L., Heath Nier, Matthew Hammer, E. Marie Southerland, Christopher L. Ardell, Eric Beaumont, Bruce H. KenKnight, and J. Andrew Armour. 2017. Defining the Neural Fulcrum for Chronic Vagus Nerve Stimulation: Implications for Integrated Cardiac Control. The Journal of Physiology 595(22):6887–6903. Doi: 10.1113/JP274678
Baffour-Awuah, Biggie, Melissa J. Pearson, Gudrun Dieberg, Jonathan D. Wiles, and Neil A. Smart. 2023. An Evidence-Based Guide to the Efficacy and Safety of Isometric Resistance Training in Hyper-tension and Clinical Implications. Clinical Hypertension 29(1):9.
Doi: 10.1186/s40885-022-00232-3
Bohn, L., Soto-Rodríguez, F. J., Ribeiro, F., & Oliveira, J. (2025). Association between objectively measured physical activity and heart rate variability in healthy adults receiving primary health care. Retos, 63, 50–62. https://doi.org/10.47197/retos.v63.109724
Brockmann, Lars, and Kenneth J. Hunt. 2023a. Heart Rate Variability Changes with Respect to Time and Exercise Intensity during Heart-Rate-Controlled Steady-State Treadmill Running. Scientific Reports 13(1):1–11. Doi: 10.1038/s41598-023-35717-0
Cohen, Daniel D., Gustavo Aroca‐Martinez, Javier Carreño‐Robayo, Alvaro Castañeda‐Hernández, Ya-neth Herazo‐Beltran, Paul A. Camacho, Johanna Otero, Daniel Martinez‐Bello, Jose P. Lopez‐Lopez, and Patricio Lopez‐Jaramillo. 2023. Reductions in Systolic Blood Pressure Achieved by Hypertensives with Three Isometric Training Sessions per Week Are Maintained with a Single Session per Week. The Journal of Clinical Hypertension 25(4):380–87. Doi: 10.1111/jch.14621
Decaux, Anthony, Jamie J. Edwards, Harry T. Swift, Philip Hurst, Jordan Hopkins, Jonathan D. Wiles, and Jamie M. O’Driscoll. 2022. Blood Pressure and Cardiac Autonomic Adaptations to Isometric Exercise Training: A Randomized Sham‐controlled Study. Physiological Reports 10(2).
Doi: 10.14814/phy2.15112
El-Malahi, Ouahiba, Darya Mohajeri, Raluca Mincu, Alexander Bäuerle, Korbinian Rothenaicher, Ramtin Knuschke, Christos Rammos, Tienush Rassaf, and Julia Lortz. 2024. Beneficial Impacts of Physical Activity on Heart Rate Variability: A Systematic Review and Meta-Analysis. PLOS ONE 19(4): e0299793. Doi: 10.1371/journal.pone.0299793
Geovanini, Glaucylara Reis, Enio Rodrigues Vasques, Rafael De Oliveira Alvim, José Geraldo Mill, Ro-drigo Varejão Andreão, Bruna Kim Vasques, Alexandre Costa Pereira, and Jose Eduardo Krie-ger. 2020. Age and Sex Differences in Heart Rate Variability and Vagal Specific Patterns – Bae-pendi Heart Study. Global Heart 15(1):71. Doi: 10.5334/gh.873
Leite, P. H., Melo, R. C., Mello, M. F., Silva, E.d, Borghi-Silva, A., & Catai, A. M. (2010). Heart rate respon-ses during isometric exercises in patients undergoing a phase III cardiac rehabilitation pro-gram. Revista brasileira de fisioterapia (Sao Carlos (Sao Paulo, Brazil)), 14(5), 383–389.
https://doi.org/10.1590/S1413-35552010000500006
Matusik, Patrycja S., Omar Alomar, Maryam Rafaqat Hussain, Muhammad Akrmah, Paweł T. Matusik, Daniel M. Chen, Muhammed Alomar, and Phyllis K. Stein. 2024. Heart Rate Variability and Co-ronary Artery Bypass Grafting: A Systematic Review. Reviews in Cardiovascular Medicine 25(1). Doi: 10.31083/j.rcm2501036
Michael, Scott, Kenneth S. Graham, and Glen M. Davis. 2017. Cardiac Autonomic Responses during Exercise and Post-Exercise Recovery Using Heart Rate Variability and Systolic Time Intervals—A Review. Frontiers in Physiology 8. Doi: 10.3389/fphys.2017.00301
Nieto, K. H. A., Ramirez, A. P., & Mendoza, A. R. (2023). Burden of Disease Attributable to Ischemic Heart Disease in Colombia (2015 - 2020). https://doi.org/10.21203/rs.3.rs-3236473/v1
Organización Mundial de la Salud. 2021. Enfermedades Cardiovasculares.
Https://Www.Who.Int/Es/News-Room/Fact-Sheets/Detail/Cardiovascular-Diseases-(Cvds).
Porras-Alvarez, Javier, and María Olinda Bernal-Calderón. 2019. Variabilidad de La Frecuencia Cardia-ca: Evaluación Del Entrenamiento Deportivo. Revisión de Tema. Duazary 16(2):259–69.
Doi: 10.21676/2389783X.2750
Sattar, Y., & Chhabra, L. (2023). Electrocardiogram. In StatPearls [Internet]. StatPearls Publishing.
Shaffer, Fred, and J. P. Ginsberg. 2017. An Overview of Heart Rate Variability Metrics and Norms. Fron-tiers in Public Health 5. Doi: 10.3389/fpubh.2017.00258
Suwalski, Grzegorz, and Piotr Suwalski. 2018. Successful Surgical Ablation of Atrial Fibrillation Does Not Disturb Long-Term Sinus Rhythm Variability. Interactive CardioVascular and Thoracic Sur-gery 27(4):520–24. Doi: 10.1093/icvts/ivy117
Tebar, William R., Raphael M. Ritti-Dias, Jorge Mota, Breno Q. Farah, Bruna T. C. Saraiva, Tatiana M. M. Damato, Leandro D. Delfino, Beatriz A. S. Aguilar, Amanda B. dos Santos, Stefany C. B. Silva, Luiz Carlos M. Vanderlei, and Diego G. D. Christofaro. 2020. Relationship between Domains of Physical Activity and Cardiac Autonomic Modulation in Adults: A Cross-Sectional Study. Scienti-fic Reports 10(1):15510. Doi: 10.1038/s41598-020-72663-7
Veloza, Laura, Camilo Jiménez, Daniel Quiñones, Felipe Polanía, Lida C. Pachón-Valero, and Claudia Y. Rodríguez-Triviño. 2019. Variabilidad de La Frecuencia Cardiaca Como Factor Predictor de Las Enfermedades Cardiovasculares. Revista Colombiana de Cardiología 26(4):205–10.
https://doi.org/10.1016/j.rccar.2019.01.006
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., Djousse, L., Elkind, M. S. V., Ferguson, J. F., Fornage, M., Khan, S. S., Kissela, B. M., Knutson, K. L., Kwan, T. W., Lackland, D. T., … Tsao, C. W. (2020). Heart disease and stroke statistics—2020 update a report from the American Heart Associa-tion. Circulation, 141(9), E139–E596. https://doi.org/10.1161/CIR.0000000000000757
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Copyright (c) 2025 Zully Rocío Rincón Rueda, Angie Julieth Galvis Barrios, Lucy Yarid Garzón Jaramillo, Angie Gabriela Jaimes Flórez, Adriana Marcela Jácome Hortúa, Juan Carlos Sánchez Delgado

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