Effects of Physical Exercise on Hepatic Biomarkers in Adult Individuals: A Systematic Review and Meta-Analysis

Authors

  • Luciano Lima dos Santos Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil. https://orcid.org/0000-0002-0501-3412
  • Juliana Brandão Pinto de Castro Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil. https://orcid.org/0000-0002-5656-0782
  • Diego Gama Linhares Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil. https://orcid.org/0000-0002-2901-3273
  • Andressa Oliveira Barros dos Santos Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil. https://orcid.org/0000-0002-7412-7229
  • Lilliany de Souza Cordeiro Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil. https://orcid.org/0000-0002-8606-0500
  • Claudio Joaquim Borba-Pinheiro Federal Institute of Pará, Pará State University, Pará 68459-876, Brazil https://orcid.org/0000-0002-9749-5825
  • Rodrigo Gomes de Souza Vale Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil. https://orcid.org/0000-0002-3049-8773

DOI:

https://doi.org/10.47197/retos.v49.98939

Keywords:

exercise; liver disease; non-alcoholic fatty liver disease; biomarkers; resistance training; high-intensity interval training

Abstract

Objective: This study aimed to analyze the effects of physical exercise on hepatic biomarkers in adult individuals. Methods: We conducted a systematic review and meta-analysis following the PRISMA recommendations and registered in PROSPERO (CRD42022337749). MEDLINE (via PubMed), Scopus, SPORTDiscus, and Web of Science were searched, using the terms of the Medical Subject Headings (MeSH) “exercise”, “liver diseases”, and “biomarkers”. Results: Fourteen studies achieved eligibility with a total of 485 participants. Interventions ranged from 4 to 12 weeks, lasting 24 to 90 minutes per session, with 3 to 5 sessions per week. Interventions with aerobic and resistance exercises, with or without a vibration device and diet implementation, demonstrated a reduction in different hepatic biomarkers, such as aspartate transferase (AST), alanine transferase (ALT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), albumin (ALB), ferritin (Fe), and indirect bilirubin (Bil). The main results of the meta-analysis showed no significant difference in ALB, GGT, AST, and ALP. However, there was a significant difference in ALT (SMD: – 0.41; 95% CI: – 0.71 to -0.11; p = 0.008; I2 = 0%). Conclusion: Physical exercise (e.g., resistance training, aerobic training, high-intensity interval training) favored the reduction of AST, ALT, GGT, ALP, ALB, Fe, and Bil. This study pointed out that the regular practice of physical exercise can be an efficient and recommended strategy to minimize the deleterious effects of liver diseases.

Keywords: exercise; liver disease; non-alcoholic fatty liver disease; biomarkers; resistance training; high-intensity interval training.

Author Biographies

  • Luciano Lima dos Santos, Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil.

    Master's student in exercise and sport science at the State University of Rio de Janeiro; Graduation of BACHELOR IN PHYSICAL EDUCATION by the SCHOOL OF EDUCATION
    ARMY PHYSICS (2001) and degree in MILITARY SCIENCES (Infantry) from Academia Militar das Agulhas Negras (1997) and postgraduate degree in MILITARY SCIENCES
    by the Officer Improvement School (2006). He is currently the Chief of the Teaching, Research, Sport and Management Division of the Army's Physical Training Center -
    BRAZILIAN ARMY. He has experience in the field of Physical Education, with an emphasis on Sports Management and Sports Training.

    https://lattes.cnpq.br/9764814774194032

  • Juliana Brandão Pinto de Castro , Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil.

    PhD in Exercise and Sport Sciences, by the Institute of Physical Education and Sports (IEFD), of the State University of Rio de Janeiro (UERJ). Master in Food, Nutrition and Health, by the Institute of Nutrition, UERJ. Graduated in Full Degree in Physical Education from UERJ. Researcher at the Exercise and Sport Laboratory (LABEES/UERJ). Substitute teacher at the Institute of Physical Education and Sports (IEFD/UERJ), for the disciplines Sports Training Methodology I and Sports Training Methodology II (2011 to 2018). She has a postgraduate degree in Higher Education Teaching. She has a postgraduate degree in Geriatrics and Gerontology from the Faculty of Medical Sciences (FCM / UERJ). She was monitor of Sports Training I and Sports Training II (IEFD / UERJ). She was a fellow at the Laboratory of Physiology applied to Physical Education (LAFISAEF / UERJ), in the Extension Project: Physical Education and Health Promotion, Subproject: Physical Exercises adapted for Hypertensive, Diabetic, Fibromyalgia, Obese, Pregnancy and Childbirth. She served as an athletics referee, category A, at the Brazilian Athletics Confederation (CBAt). She holds the Aquatic Exercise Association (AEA) International Aquatic Exercise Instructor Certification. She is certified by the University of Cambridge, ESOL Examinations, First Certificate in English (FCE).

    http://lattes.cnpq.br/1748355855522277

  • Diego Gama Linhares, Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil.

    Master's student in exercise and sport science at the State University of Rio de Janeiro and member of LABEES (exercise and sport laboratory) of the graduate program in exercise and sport sciences at UERJ; Specialization in exercise physiology and morphofunctional evaluation; Specialization in neuromotor physiology; Specialization in biomechanics, kinesiology and physical training; Degree in Physical Education. Currently professor and coordinator at Estácio de Sá University in the Physical Education course; Personal trainer for special groups; Studio owner Diego Gama personal trainer; Professor of Physical Education at the Secretary of Education of the state of Rio de Janeiro and the municipality of Campos dos Goytacazes; Pilates training; IV Dan Black Belt (International Instructor) in Taekwondo ITF.

    http://lattes.cnpq.br/8010962149280671

  • Andressa Oliveira Barros dos Santos, Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil.

    PhD student in Exercise and Sport Sciences - State University of Rio de Janeiro; Master in Exercise and Sport Sciences - State University of Rio de Janeiro; Post Graduated in Human Anatomy and Biomechanics from Castelo Branco University 2020; Bachelor's Degree in Physical Education from Universidade Augusto Motta; Graduated in Full Degree in Physical Education from Castelo Branco University. Researcher at the Exercise and Sport Laboratory (LABEES/UERJ). Researcher at the Performance, Biodynamics, Exercise and Health Research Group (BIODESA), Castelo Branco University, Rio de Janeiro, Brazil. He was a scientific initiation scholarship holder - PBICT Universidade Castelo Branco; Associate Member of the Brazilian Society of Anatomy; Participated in the Brazilian Congress of Anatomy in the State of Paraíba 2018; Participated in the Mini Course on Clinical Anatomy of the Brachial and Lumbosacral Plexuses at the XXVIII Brazilian Congress of Anatomy promoted by the Brazilian Society of Anatomy 2018; Monitoring in Human Anatomy at Castelo Branco University 2016 to 2018. Extension course: bodybuilding applied to personalized training; 2. Extension course: Kinesiology and biomechanics applied to bodybuilding; certification: Spinal Health Training; Anatomical Techniques Course, Federal University of Medicine of the state of Ceará; Integrated Functional Training Course; Internship in monitoring at the Human Anatomy laboratory at Castelo Branco University; Non-compulsory internship in Physical Education with disabled children, in the pedagogical auxiliary role, at SME/E/CRE.

    http://lattes.cnpq.br/2385822532852535

  • Lilliany de Souza Cordeiro, Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil.

    Degree in Physical Education from the Federal University of Rio de Janeiro (1993), a Master's in Human Motricity Science from Castelo Branco University (2004) and a PhD in Educational Sciences from the American University (2017). Currently a professor at the Instituto Federal Fluminense-Campus Macaé. Served as a professor at the State Department of Education in Rio de Janeiro, as a physical education teacher at the Municipality of Campos dos Goytacazes and as a master professor at Faculdade Metropolitana São Carlos. She has experience in the area of Physical Education, with an emphasis on Physical Activity / Autonomy / Quality of Life for the Elderly and Teacher Training.


    http://lattes.cnpq.br/1353116513795725

  • Claudio Joaquim Borba-Pinheiro, Federal Institute of Pará, Pará State University, Pará 68459-876, Brazil

    Prof. PHD Claudio Joaquim Borba-Pinheiro, CREF n° 004560-G/PA PhD in Sciences from the Federal University of the State of Rio de Janeiro (UNIRIO-RJ, 2013). Master's Degree in Human Motricity Sciences from Castelo Branco University (UCB-RJ, 2009). Specialization in Judo (EsEFEx/UFRJ, 2001). Graduated in Degree/Bachelor in Physical Education from the University of the State of Pará (UEPA-PA, 1996), He is a Full Professor at the Federal Institute of Pará (IFPA), where he is accredited in the Stricto Sensu Professional Master's Program in Professional and Technological Education of the Federal Network (ProfPET). Professor at the University of the State of Pará (UEPA) both on the campuses of Tucuruí-PA, Brazil. He is a member of the Center for Studies and Research on Fights and Combat Sports (NEPLEC / UFPA). He has experience in the area of Physical Education with an emphasis on physical exercise methods for people's health and also in combat sports. The main variables studied are: bone mineral density, balance, cardiorespiratory resistance, muscle strength, balance, functional autonomy and quality of life. In addition, he is an ad hoc consultant for several national and international scientific journals, has published 75 scientific articles, supervised 40 undergraduate works, 13 Lato Sensu postgraduate studies and 8 scientific initiation works (PIBIC). He has also published 56 book chapters and six books.
    http://lattes.cnpq.br/3169671245744894

  • Rodrigo Gomes de Souza Vale, Postgraduate Program in Exercise and Sport Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil and Laboratory of Exercise and Sport, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil.

    Degree in Physical Education (UFRJ), a Master's degree in Human Motricity Science (UCB/RJ), a PhD in Health Sciences (UFRN) and a postdoctoral degree in Biosciences (UNIRIO). He is an associate professor at the Institute of Physical Education and Sports (IEFD) and the Stricto Sensu Graduate Program in Exercise and Sports Sciences (PPGCEE) at the State University of Rio de Janeiro (UERJ). He is coordinator of the Exercise and Sport Laboratory (LABEES-UERJ). He is a full professor, coordinator of the Exercise Physiology Laboratory (LAFIEX) and of the Physical Education course at Estácio de Sá University (UNESA-Cabo Frio / RJ). He has experience in the area of Physical Education and Health, with an emphasis on Physical Conditioning, Training, Biomechanics and Exercise Physiology, Physical Activity, Health and Quality of Life. He is a researcher on topics on: assessment, balance, falls and posture, electromyography, thermography, strength training, aerobics and flexibility, hormones, quality of life, autonomy and aging.
    http://lattes.cnpq.br/2560385858295114

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Published

28-06-2023

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Vol. 49 (2023)

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Theoretical systematic reviews and/or meta-analysis

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How to Cite

dos Santos, L. L., Pinto de Castro , J. B. ., Gama Linhares, D. ., Barros dos Santos, A. O., de Souza Cordeiro, L., Borba-Pinheiro, C. J., & Gomes de Souza Vale, R. . (2023). Effects of Physical Exercise on Hepatic Biomarkers in Adult Individuals: A Systematic Review and Meta-Analysis. Retos, 49, 762-774. https://doi.org/10.47197/retos.v49.98939