Effect of an anti-inflammatory diet on the psychomotor profile of children with Autism Spectrum Disorder: a pilot study

Authors

DOI:

https://doi.org/10.47197/retos.v74.117914

Keywords:

Autism spectrum disorder, child, neurodevelopmental disorders, nutritional therapy, psychomotor performance

Abstract

Introduction: Autism Spectrum Disorder (ASD) is characterized by multiple difficulties in psychomotor development that affect the performance of daily activities and social participation. Several studies have suggested that diet and the balance of the gut microbiota can positively influence the neurodevelopment and functioning characteristics of people with ASD. Objetive:  This study explores the effect of an anti-inflammatory diet on psychomotor profiles of children with ASD.

Methodology: A quasi-experimental study was conducted with 18 children diagnosed with ASD: 9 in the experimental group and 9 in the control group, and 12 neurotypical children: 6 in the experimental group and 6 in the control group. Patients were evaluated before and after a 12-week anti-inflammatory nutritional intervention. Sociodemographic and clinical characteristics, nutritional status, muscle tone, balance, laterality, spatiotemporal structuring, body notion, global praxia, fine praxia, and psychomotor profile were evaluated.

Results: There were significant improvements (p<0.05) in children with ASD in tonicity factors, fine praxia and psychomotor profile. The effect size was large in several domains (d>0.8), indicating substantial changes owing to the intervention.

Discussion: These findings support the integration of nutritional interventions into interdisciplinary therapeutic programs in clinical and educational contexts. However, further robust studies are required to confirm this.

Conclusions:  Implementation of an anti-inflammatory diet can improve the psychomotor profile of children with ASD.

References

Adams, J. B., Audhya, T., Geis, E., Gehn, E., Fimbres, V., Pollard, E. L., Mitchell, J., Ingram, J., Hellmers, R., Laake, D., Matthews, J. S., Li, K., Naviaux, J. C., Naviaux, R. K., Adams, R. L., Coleman, D. M., & Quig, D. W. (2018). Comprehensive nutritional and dietary intervention for autism spectrum disor-der: A randomized, controlled 12-month trial. Nutrients, 10(3), 369. https://doi.org/10.3390/nu10030369

Al-Beltagi, M. (2024). Nutritional management and autism spectrum disorder: A systematic review. World Journal of Clinical Pediatrics, 13(4), 99649. https://doi.org/10.5409/wjcp.v13.i4.99649

Alsayegh, A. A., Al Areefy, A. A., & Ahmed, M. M. (2025). Effect of therapeutic diet along with special physiotherapy program on gross motor development and cognitive function in autistic chil-dren: A randomized controlled trial. Journal of Disability Research, 4(1), 20240109. https://doi.org/10.57197/jdr-2024-0109

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5.ª ed.). American Psychiatric Publishing. https://doi.org/10.1176/appi.books.9780890425596

Bölte, S., De Schipper, E., Robison, J. E., Wong, V. C. N., Selb, M., Singhal, N., De Vries, P. J., & Zwaigen-baum, L. (2014). Classification of functioning and impairment: The development of ICF core sets for autism spectrum disorder. Autism Research, 7(1), 167–172. https://doi.org/10.1002/aur.1335

Byrska, A., Błażejczyk, I., Faruga, A., Potaczek, M., Wilczyński, K. M., & Janas-Kozik, M. (2023). Patterns of food selectivity among children with autism spectrum disorder. Journal of Clinical Medicine, 12(17), 5469. https://doi.org/10.3390/jcm12175469

Chen, L. C., Su, W. C., Ho, T. L., Lu, L., Tsai, W. C., Chiu, Y. N., & Jeng, S. F. (2019). Postural control and in-terceptive skills in children with autism spectrum disorder. Physical Therapy, 99(9), 1231–1241. https://doi.org/10.1093/ptj/pzz084

Da Fonseca, V. (1998). Manual de observación psicomotriz. Editorial Trillas.

Da Silva, S. H., Felippin, M. R., De Oliveira Medeiros, L., Hedin-Pereira, C., & Nogueira-Campos, A. A. (2025). A scoping review of motor impairments in autism spectrum disorder. Neuroscience & Biobehavioral Reviews, 169, 106002. https://doi.org/10.1016/j.neubiorev.2025.106002

Díaz, D., & Leonario, M. (2022). Effectiveness of nutritional interventions on behavioral symptomatol-ogy of autism spectrum disorder: A systematic review. Nutrición Hospitalaria, 39(6), 1378–1388. https://doi.org/10.20960/nh.04155

Elbasan, B., Kayihan, H., & Duzgun, I. (2012). Sensory integration and activities of daily living in children with developmental coordination disorder. Italian Journal of Pediatrics, 38(14). https://doi.org/10.1186/1824-7288-38-14

Elbaum, B., Gattamorta, K. A., & Penfield, R. D. (2010). Evaluation of the Battelle Developmental Inven-tory, 2nd edition, screening test for use in states’ child outcomes measurement systems. Journal of Early Intervention, 32(4), 255–273. https://doi.org/10.1177/1053815110384723

Elshamy, R., Tarboush, H., Alghfeli, B., Alameeri, Z. M., AlAli, A. K. S., & Fityan, M. (2025). Dietary inter-ventions in children with autism spectrum disorder: Contemporary overview. Discover Medi-cine, 2(1), 1–22. https://doi.org/10.1007/s44337-025-00400-y

Fournier, K. A., Hass, C. J., Naik, S. K., Lodha, N., & Cauraugh, J. H. (2010). Motor coordination in autism spectrum disorders: A synthesis and meta-analysis. Journal of Autism and Developmental Dis-orders, 40(10), 1227–1240. https://doi.org/10.1007/s10803-010-0981-3

Harris, S. R. (2017). Early motor delays as diagnostic clues in autism spectrum disorder. European Journal of Pediatrics, 176(9), 1259–1262. https://doi.org/10.1007/s00431-017-2951-7

Instituto Colombiano de Bienestar Familiar. (2018). Tabla de composición de alimentos. www.icbf.gov.co/nutricion/tabla-de-composicion-de-alimentos-colombianos

Majhi, S., Kumar, S., & Singh, L. (2023). A review on autism spectrum disorder: Pathogenesis, bi-omarkers, pharmacological and non-pharmacological interventions. CNS & Neurological Disor-ders – Drug Targets, 22(5), 659–677. https://doi.org/10.2174/1871527321666220428134802

Marko, M. K., Crocetti, D., Hulst, T., Donchin, O., Shadmehr, R., & Mostofsky, S. H. (2015). Behavioural and neural basis of anomalous motor learning in children with autism. Brain, 138(3), 784–797. https://doi.org/10.1093/brain/awu394

Matthews, J. S., & Adams, J. B. (2023). Ratings of the effectiveness of 13 therapeutic diets for autism spectrum disorder: Results of a national survey. Journal of Personalized Medicine, 13(10), 1448. https://doi.org/10.3390/jpm13101448

Memari, A. H., Ghanouni, P., Shayestehfar, M., & Ghaheri, B. (2014). Postural control impairments in individuals with autism spectrum disorder: A critical review. Asian Journal of Sports Medicine, 5(3), e22963. https://doi.org/10.5812/asjsm.22963

Ministerio de Salud y Protección Social. (2016). Resolución 2465 de 2016. https://www.minsalud.gov.co/Normatividad_Nuevo/Forms/DispForm.aspx?ID=4909

Ministerio de Salud y Protección Social. (2016, 22 de agosto). Resolución 3803 de 2016. Diario Oficial No. 49 976. https://www.minsalud.gov.co/Normatividad_Nuevo/Resolución%203803%20de%202016.pdf

Mohd Nordin, A., Ismail, J., & Kamal Nor, N. (2021). Motor development in children with autism spec-trum disorder. Frontiers in Pediatrics, 9, 598276. https://doi.org/10.3389/fped.2021.598276

Molina-López, J., Leiva-García, B., Planells, E., & Planells, P. (2021). Food selectivity, nutritional inade-quacies and mealtime behavioral problems in children with autism spectrum disorder. Interna-tional Journal of Eating Disorders, 54(12), 2155–2166. https://doi.org/10.1002/eat.23631

Montiel Arreaga, R. C., Culque Nuñez, C. A., Zurita Espinoza, K. J., & Baidal Tircio, R. A. (2025). Fomen-tando el desarrollo integral: El rol del juego en programas de educación física y recreación para niños con TEA. Retos, 68, 1710–1720. https://doi.org/10.47197/retos.v68.116450

Naranjo-Galvis, C. A., Trejos-Gallego, D. M., Correa-Salazar, C., Triviño-Valencia, J., Valencia-Buitrago, M., Ruiz-Pulecio, A. F., Méndez-Ramírez, L. F., Zabaleta, J., Meñaca-Puentes, M. A., Ruiz-Villa, C. A., Orjuela-Rodríguez, M., Carmona-Hernández, J. C., & Salamanca-Duque, L. M. (2025). Anti-inflammatory diet and probiotic supplementation as strategies to modulate immune dysregula-tion in autism spectrum disorder. Nutrients, 17(16), 2664. https://doi.org/10.3390/nu17162664

Nova, R., Morales, G., & Ahumada, D. (2022). Factores nutricionales y alimentarios asociados al desarro-llo y comportamiento del espectro autista: Un resumen de la evidencia. Revista Chilena de Nu-trición, 49(6), 753–759. https://doi.org/10.4067/s0717-75182022000700753

Ohara, R., Kanejima, Y., Kitamura, M., & Izawa, K. P. (2019). Association between social skills and motor skills in individuals with autism spectrum disorder: A systematic review. European Journal of Investigation in Health, Psychology and Education, 10(1), 276–296. https://doi.org/10.3390/ejihpe10010022

Oliveira, K. S. C., Fontes, D. E., Longo, E., Leite, H. R., & Camargos, A. C. R. (2023). Motor skills are associ-ated with participation of children with autism spectrum disorder. Journal of Autism and De-velopmental Disorders, 53(4), 1403–1412. https://doi.org/10.1007/s10803-021-05318-9

Pan, C. Y., Chu, C. H., Tsai, C. L., Sung, M. C., Huang, C. Y., & Ma, W. Y. (2016). The impacts of physical ac-tivity intervention on physical and cognitive outcomes in children with autism spectrum disor-der. Autism, 21(2), 190–202. https://doi.org/10.1177/1362361316633562

Paquet, A., Olliac, B., Golse, B., & Vaivre-Douret, L. (2015). Current knowledge on motor disorders in children with autism spectrum disorder. Child Neuropsychology, 22(7), 763–794. https://doi.org/10.1080/09297049.2015.1085501

Paquet, A., Olliac, B., Golse, B., & Vaivre-Douret, L. (2019). Nature of motor impairments in autism spec-trum disorder: A comparison with developmental coordination disorder. Journal of Clinical and Experimental Neuropsychology, 41(1), 1–14. https://doi.org/10.1080/13803395.2018.1483486

Pérez-Cabral, I. D., Bernal-Mercado, A. T., Islas-Rubio, A. R., Suárez-Jiménez, G. M., Robles-García, M. Á., Puebla-Duarte, A. L., & Del-Toro-Sánchez, C. L. (2024). Exploring dietary interventions in autism spectrum disorder. Foods, 13(18), 3010. https://doi.org/10.3390/foods13183010

Ranieri, A., Mennitti, C., Falcone, N., La Monica, I., Di Iorio, M. R., Tripodi, L., Gentile, A., Vitale, M., Pero, R., Pastore, L., D’Argenio, V., Scudiero, O., & Lombardo, B. (2023). Positive effects of physical ac-tivity in autism spectrum disorder: How it influences behavior, metabolic disorder and gut mi-crobiota. Frontiers in Psychiatry, 14, 1238797. https://doi.org/10.3389/fpsyt.2023.1238797

Reyes Oyola, F. A., Palomino Devia, C., & Aponte López, N. W. (2025). Desarrollo motor grueso en esco-lares colombianos. Retos, 71, 641–654. https://doi.org/10.47197/retos.v71.116345

Romero Lozano, H., Quintero Reina, M., Romero Cuestas, C. A., Andrades Grassi, J. E., & Prado Pérez, J. R. (2025). Perfil motriz de niños escolares en condición de discapacidad intelectual. Retos, 71, 174–190. https://doi.org/10.47197/retos.v71.115815

Ruggeri, A., Dancel, A., Johnson, R., & Sargent, B. (2019). The effect of motor and physical activity inter-vention on motor outcomes of children with autism spectrum disorder: A systematic review. Autism, 24(3), 544–568. https://doi.org/10.1177/1362361319885215

Salamanca, L. M., Naranjo, M. M., Díaz, L. M., & Salinas, R. I. (2016). Cross-sectional study of develop-mental coordination disorder with behavior problems. Revista Ciencias de la Salud, 14(3), 351–363. https://doi.org/10.12804/revsalud14.03.2016.04

Srikantha, P., & Mohajeri, M.H. (2019). The possible role of the microbiota–gut–brain axis in autism spectrum disorder. International Journal of Molecular Sciences, 20(9), 2115. https://doi.org/10.3390/ijms20092115

Tomova, A., Soltys, K., Kemenyova, P., Karhanek, M., & Babinska, K. (2020). The influence of food intake specificity in children with autism on gut microbiota. International Journal of Molecular Sci-ences, 21(8), 2797. https://doi.org/10.3390/ijms21082797

Tye, C., Runicles, A. K., Whitehouse, A. J. O., & Alvares, G. A. (2019). Characterizing the interplay between autism spectrum disorder and comorbid medical conditions: An integrative review. Frontiers in Psychiatry, 9, 751. https://doi.org/10.3389/fpsyt.2018.00751

Wang, L. A. L., Petrulla, V., Zampella, C. J., Waller, R., & Schultz, R. T. (2022). Gross motor impairment and its relation to social skills in autism spectrum disorder: A systematic review and two meta-analyses. Psychological Bulletin, 148(4), 273–300. https://doi.org/10.1037/bul0000358

Wang, Q., Yang, Q., & Liu, X. (2023). The microbiota–gut–brain axis and neurodevelopmental disorders. Protein & Cell, 14(10), 762–775. https://doi.org/10.1093/procel/pwad026

Whyatt, C., & Craig, C. (2013). Sensory–motor problems in autism. Frontiers in Integrative Neurosci-ence, 7, 51. https://doi.org/10.3389/fnint.2013.00051

Yu, Y., Huang, J., Chen, X., Fu, J., Wang, X., Pu, L., Gu, C., & Cai, C. (2022). Efficacy and safety of diet thera-pies in children with autism spectrum disorder: A systematic review and meta-analysis. Fron-tiers in Neurology, 13, 844117. https://doi.org/10.3389/fneur.2022.844117

Downloads

Published

01-01-2026

Issue

Section

Original Research Article

How to Cite

Salamanca Duque, L. M., Trejos Gallego, D. M., Triviño Valencia, J., Valencia Buitrago, M., Meñaca Puentes, M. A., Ruiz Villa, C. A., Orjuela Rodríguez, M., & Naranjo Galvis, C. A. (2026). Effect of an anti-inflammatory diet on the psychomotor profile of children with Autism Spectrum Disorder: a pilot study. Retos, 74, 673-687. https://doi.org/10.47197/retos.v74.117914