Impact of home-based physical exercises and diet management on functional performance and depression among Vitamin D deficient females
DOI:
https://doi.org/10.47197/retos.v73.117736Keywords:
Exercise, diet therapy, functional performance, depression, Vitamin D3Abstract
Background: This study investigated the impact of different interventions on depression and functional performance in females with vitamin D3 deficiency, a condition found to be two to three times more prevalent in women and associated with various symptoms.
Methods: A total of 120 women were randomly assigned to four equal groups; Group A had a home exercise regimen, sun exposure, and vitamin D3 supplement; Group B had a diet, sun exposure, and vitamin D3 supplement; Group C received sun exposure and a vitamin D3 supplement; and Group D received no intervention.
Results: Over the study period, significant improvements were observed in Groups A, B, and C compared to Group D. These included increases in vitamin D3 levels and improved physical function, measured by the 6-minute walk test (p < 0.05), and reductions in depression and dyspnea, measured by the Hamilton Depression Rating Scale (HAMD) and Dyspnea Borg Scale respectively (p < 0.001). Further analysis revealed that Groups A and B had greater reductions in depression scores than Group C (p < 0.01), though no significant difference was observed between Groups A and B (p > 0.05). Group A also showed a significantly greater improvement in dyspnea scores compared to Groups B and C (p < 0.01), while there was no difference between Groups B and C in this regard (p > 0.05).
Conclusion: Therapeutic methods affected depression and functional performance in females with vitamin D3 deficiency, but exercise combined with Vitamin D3 supplement was more effective.
References
Abrams, G. D., Feldman, D., & Safran, M. R. (2018). Effects of vitamin D on skeletal muscle and athletic performance. Journal of the American Academy of Orthopaedic Surgeons, 26(8), 278–285. https://doi.org/10.5435/JAAOS-D-16-00724
Al-Daghri, N. M. (2018). Vitamin D in Saudi Arabia: Prevalence, distribution and disease associations. Journal of Steroid Biochemistry and Molecular Biology, 175, 102–107. https://doi.org/10.1016/j.jsbmb.2016.12.017
Al-Faris, N. A. (2016). High prevalence of vitamin D deficiency among pregnant Saudi women. Nutrients, 8(2), 77. https://doi.org/10.3390/nu8020077
Alharthi, H. A. (2020). Effect of vitamin D3 supplementation on 25-hydroxyvitamin D status in healthy women in Jeddah: Implication to health markers. [Unpublished manuscript].
AlMulhim, A. S., AlMulhim, A. I., AlMulhim, A. A., et al. (2015). The effect of exercise in vitamin D level in Saudi female. International Journal of Current Research and Academic Review, 3, 251–257.
Al-Othman, A., Al-Musharaf, S., Al-Daghri, N. M., et al. (2012). Effect of physical activity and sun exposure on vitamin D status of Saudi children and adolescents. BMC Pediatrics, 12, 92. https://doi.org/10.1186/1471-2431-12-92
Anglin, R. E. S., Samaan, Z., Walter, S. D., & McDonald, S. D. (2013). Vitamin D deficiency and depression in adults: Systematic review and meta-analysis. British Journal of Psychiatry, 202(2), 100–107. https://doi.org/10.1192/bjp.bp.111.106666
Anglin, R. E. S., Samaan, Z., Walter, S. D., & McDonald, S. D. (2013). Vitamin D deficiency and depression in adults: Systematic review and meta-analysis. British Journal of Psychiatry, 202(2), 100–107. https://doi.org/10.1192/bjp.bp.111.106666
Autier, P., Boniol, M., Pizot, C., & Mullie, P. (2014). Vitamin D status and ill health: A systematic review. The Lancet Diabetes & Endocrinology, 2(1), 76–89. https://doi.org/10.1016/S2213-8587(13)70165-7
Bigman, G. (2022). Vitamin D metabolites, D3 and D2, and their independent associations with depression symptoms among adults in the United States. Nutritional Neuroscience, 25(4), 648–656. https://doi.org/10.1080/1028415X.2020.1794422
Bischoff-Ferrari, H. A., Freystätter, G., Vellas, B., et al. (2022). Effects of vitamin D, omega-3 fatty acids, and a simple home strength exercise program on fall prevention: The DO-HEALTH randomized clinical trial. American Journal of Clinical Nutrition, 115(5), 1311–1321. https://doi.org/10.1093/ajcn/nqac022
Bouillon, R., Marcocci, C., Carmeliet, G., et al. (2019). Skeletal and extraskeletal actions of vitamin D: Current evidence and outstanding questions. Endocrine Reviews, 40(4), 1109–1151. https://doi.org/10.1210/er.2018-00126
Bouillon, R., Norman, A. W., & Lips, P. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(19), 1980–1982. https://doi.org/10.1056/NEJMc072359
Boulkrane, M. S., Fedotova, J., Kolodyaznaya, V., et al. (2020). Vitamin D and depression in women: A mini-review. Current Neuropharmacology, 18(4), 288–300. https://doi.org/10.2174/1570159X17666191108111120
Bunout, D., Barrera, G., Leiva, L., et al. (2006). Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Experimental Gerontology, 41(8), 746–752. https://doi.org/10.1016/j.exger.2006.05.001
Carswell, A. T., Oliver, S. J., Wentz, L. M., et al. (2018). Influence of vitamin D supplementation by sunlight or oral D3 on exercise performance. Medicine & Science in Sports & Exercise, 50(12), 2555–2564. https://doi.org/10.1249/MSS.0000000000001795
Cashman, K. D., Dowling, K. G., Škrabáková, Z., et al. (2016). Vitamin D deficiency in Europe: Pandemic? American Journal of Clinical Nutrition, 103(4), 1033–1044. https://doi.org/10.3945/ajcn.115.120873
Cegielski, J., Brook, M. S., Quinlan, J. I., Wilkinson, D. J., Smith, K., Atherton, P. J., & Phillips, B. E. (2017). A 4-week, lifestyle-integrated, home-based exercise training programme elicits improvements in physical function and lean mass in older men and women: A pilot study. F1000Research, 6, 1235. https://doi.org/10.12688/f1000research.11656.1
Crescioli, C. (2020). Vitamin D merging into immune system–skeletal muscle network: Effects on human health. Applied Sciences, 10(16), 5592. https://doi.org/10.3390/app10165592
de la Puente Yagüe, M., Collado-Yurrita, L., Ciudad-Cabañas, M. J., Cuadrado-Cenzual, M. Á., & Hernández-Cabria, M. (2020). Role of vitamin D in athletic performance and recovery. Nutrients, 12(6), 1790. https://doi.org/10.3390/nu12061790
Dominguez, L. J., Farruggia, M., Veronese, N., & Barbagallo, M. (2021). Vitamin D sources, metabolism, and deficiency: Available compounds and guidelines for its treatment. Metabolites, 11(4), 255. https://doi.org/10.3390/metabo11040255
Elshafie, D. E., Al-Khashan, H. I., & Mishriky, A. M. (2012). Comparison of vitamin D deficiency in Saudi married couples. European Journal of Clinical Nutrition, 66(6), 742–745. https://doi.org/10.1038/ejcn.2012.29
Fischer, C., Jakob, F., Kohl, M., et al. (2023). Additive effects of exercise and vitamin D supplementation (with and without calcium) on bone mineral density in older adults: A systematic review and meta-analysis. Journal of Osteoporosis, 2023, 5570030. https://doi.org/10.1155/2023/5570030
Holick, M. F. (2017). The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Reviews in Endocrine and Metabolic Disorders, 18(2), 153–165. https://doi.org/10.1007/s11154-017-9424-1
Hoseini, Z., Behpour, N., & Hoseini, R. (2020). Co-treatment with vitamin D supplementation and aerobic training in elderly women with vitamin D deficiency and NAFLD: A single-blind controlled trial. Hepatitis Monthly, 20(1).
Ibrahim, A. K., Almalki, M. H., Al-Daghri, N. M., & Holick, M. F. (2015). Optimum sun exposure times for vitamin D status correction in Saudi Arabia. European Journal of Preventive Medicine, 3(5), 147–154.
Irandoust, K., & Taheri, M. (2017). The effect of vitamin D supplement and indoor vs outdoor physical activity on depression of obese depressed women. Asian Journal of Sports Medicine, 8(3), e13863.
Jolliffe, D. A., Camargo, C. A., Jr., Sluyter, J. D., et al. (2021). Vitamin D supplementation to prevent acute respiratory infections: A systematic review and meta-analysis of aggregate data from randomised controlled trials. The Lancet Diabetes & Endocrinology, 9(5), 276–292. https://doi.org/10.1016/S2213-8587(21)00051-6
Kendrick, K. R., Baxi, S. C., & Smith, R. M. (2000). Usefulness of the modified 0–10 Borg scale in assessing the degree of dyspnea in patients with COPD and asthma. Journal of Emergency Nursing, 26(3), 216–222. https://doi.org/10.1016/S0099-1767(00)90093-X
Laird, E., Ward, M., McSorley, E., et al. (2010). Vitamin D and bone health: Potential mechanisms. Nutrients, 2(7), 693–724. https://doi.org/10.3390/nu2070693
Lips, P., Cashman, K. D., Lamberg-Allardt, C., et al. (2019). Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: A position statement of the European Calcified Tissue Society. European Journal of Endocrinology, 180(4), P23–P54. https://doi.org/10.1530/EJE-18-0736
Lips, P., van Schoor, N. M., & de Jongh, R. T. (2014). Diet, sun, and lifestyle as determinants of vitamin D status. Annals of the New York Academy of Sciences, 1317(1), 92–98. https://doi.org/10.1111/nyas.12443
Malczewska-Lenczowska, J., Surała, O., Granda, D., et al. (2024). The relationship between bone health parameters, vitamin D and iron status, and dietary calcium intake in young males. Nutrients, 16(2), 215. https://doi.org/10.3390/nu16020215
Manson, J. E., Bassuk, S. S., & Buring, J. E.; VITAL Research Group. (2020). Principal results of the VITamin D and OmegA-3 TriaL (VITAL) and updated meta-analyses of relevant vitamin D trials. Journal of Steroid Biochemistry and Molecular Biology, 198, 105522. https://doi.org/10.1016/j.jsbmb.2019.105522
Martineau, A. R., Jolliffe, D. A., Hooper, R. L., et al. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data. BMJ, 356, i6583. https://doi.org/10.1136/bmj.i6583
Mithal, A., Wahl, D. A., Bonjour, J. P., et al. (2009). Global vitamin D status and determinants of hypovitaminosis D. Osteoporosis International, 20(11), 1807–1820. https://doi.org/10.1007/s00198-009-0954-6
Müller, M. J., & Dragicevic, A. (2003). Standardized rater training for the Hamilton Depression Rating Scale (HAMD-17) in psychiatric novices. Journal of Affective Disorders, 77(1), 65–69. https://doi.org/10.1016/S0165-0327(02)00097-6
Palacios, C., & Gonzalez, L. (2014). Is vitamin D deficiency a major global public health problem? Journal of Steroid Biochemistry and Molecular Biology, 144(Pt A), 138–145. https://doi.org/10.1016/j.jsbmb.2013.11.003
Pasco, J. A., Henry, M. J., Nicholson, G. C., et al. (2001). Vitamin D status of women in the Geelong Osteoporosis Study: Association with diet and casual exposure to sunlight. Medical Journal of Australia, 175(8), 401–405. https://doi.org/10.5694/j.1326-5377.2001.tb143643.x
Pearce, S. H., & Cheetham, T. D. (2010). Diagnosis and management of vitamin D deficiency. BMJ, 340, b5664. https://doi.org/10.1136/bmj.b5664
Pilch, W., et al. (2021). The relationship between serum vitamin D levels and exercise performance in adults. Nutrients, 13(1), 234. https://doi.org/10.3390/nu13010234
Shuler, F. D., Wingate, M. K., Moore, G. H., & Giangarra, C. (2012). Sports health benefits of vitamin D. Sports Health, 4(6), 496–501. https://doi.org/10.1177/1941738112461621
Spiro, A., & Buttriss, J. L. (2014). Vitamin D: An overview of vitamin D status and intake in Europe. Nutrition Bulletin, 39(4), 322–350. https://doi.org/10.1111/nbu.12108
Torres-Castro, R., Gimeno-Santos, E., & Blanco, I. (2022). Use of six-minute walking test to predict peak oxygen consumption in pulmonary vascular disease. Pulmonary Circulation, 12(4), e12129. https://doi.org/10.1002/pul2.12129
von Berens, Å., Fielding, R. A., Gustafsson, T., et al. (2018). Effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: The VIVE2 randomized controlled trial. BMC Geriatrics, 18(1), 286. https://doi.org/10.1186/s12877-018-0976-z
Wicherts, I. S., Boeke, A. J., van der Meer, I. M., et al. (2011). Sunlight exposure or vitamin D supplementation for vitamin D-deficient non-western immigrants: A randomized clinical trial. Osteoporosis International, 22(3), 873–882. https://doi.org/10.1007/s00198-010-1343-x
Xie, Y., Wu, Z., Sun, L., et al. (2021). The effects and mechanisms of exercise on the treatment of depression. Frontiers in Psychiatry, 12, 705559. https://doi.org/10.3389/fpsyt.2021.705559
Zhang, J., & Cao, Z. B. (2022). Exercise: A possibly effective way to improve vitamin D nutritional status. Nutrients, 14(13), 2652. https://doi.org/10.3390/nu14132652
Zhu, K., Austin, N., Devine, A., et al. (2010). A randomized controlled trial of the effects of vitamin D on muscle strength and mobility in older women with vitamin D insufficiency. Journal of the American Geriatrics Society, 58(11), 2063–2068. https://doi.org/10.1111/j.1532-5415.2010.03142.x
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