O efeito da citrulina na dor muscular tardia (DOMS) e na resistência aeróbia e anaeróbia em atletas de sub-elite
DOI:
https://doi.org/10.47197/retos.v72.114696Palavras-chave:
Citrulina, DOMS, resistência aeróbia, resistência anaeróbia, badmintonResumo
Introdução: Os atletas podem melhorar o seu desempenho ajustando a sua dieta e consumindo citrulina, um aminoácido não essencial que afeta o VO₂máx, aumentando a concentração plasmática de arginina e a produção de óxido nítrico.
Objectivo: Determinar o efeito da suplementação de citrulina durante 7 dias na DMIT e na resistência aeróbia e anaeróbia em atletas após exercício excêntrico. Este estudo investiga o impacto da suplementação com citrulina no desempenho e na resistência de atletas após exercício excêntrico, com foco nos seus efeitos no VO₂máx e na DMIT.
Metodologia: Determinar o efeito da suplementação de citrulina durante 7 dias na DMIT e na resistência aeróbia e anaeróbia em atletas após exercício excêntrico. Este estudo investiga o impacto da suplementação com citrulina no desempenho e na resistência de atletas após exercício excêntrico, com foco nos seus efeitos no VO₂máx e na DMIT.
Resultados: O grupo CIT apresentou melhorias significativas na resistência anaeróbia no pós-teste 1, mas não no pós-teste 2. Relativamente à resistência aeróbia, o grupo CIT registou melhorias significativas em ambos os pós-testes, com o maior efeito no pós-teste 2 (d = 1,892). Além disso, os níveis de dor por DMIT diminuíram mais rapidamente no grupo CIT do que no grupo PLA, com diferenças significativas (p < 0,05) às 24, 48 e 72 horas após o exercício excêntrico.
Discussão: A suplementação com citrulina aumentou a resistência aeróbia e acelerou a recuperação da DMIT, consistente com os achados de Pérez-Guisado e Jakeman (2010). O pequeno efeito na resistência anaeróbia, por outro lado, corrobora a investigação de Rhim et al. (2020), que demonstra que a variação da resposta depende dos parâmetros.
Conclusões: A suplementação com citrulina acelera a recuperação da dor muscular e melhora a resistência aeróbica e anaeróbica em atletas, aumentando a produção de óxido nítrico e reduzindo a dor muscular pós-exercício.
Referências
Aguayo, E., Martínez-Sánchez, A., Fernández-Lobato, B., & Alacid, F. (2021). L-Citrulline: A Non-Essential Amino Acid with Important Roles in Human Health. Applied Sciences 2021, Vol. 11, Page 3293, 11(7), 3293. https://doi.org/10.3390/APP11073293
Ahmad, A., Dempsey, S. K., Daneva, Z., Azam, M., Li, N., Li, P. L., & Ritter, J. K. (2018). Role of Nitric Oxide in the Cardiovascular and Renal Systems. International Journal of Molecular Sciences, 19(9), 2605. https://doi.org/10.3390/IJMS19092605
Allerton, T. D., Proctor, D. N., Stephens, J. M., Dugas, T. R., Spielmann, G., & Irving, B. A. (2018). l-Citrulline Supplementation: Impact on Cardiometabolic Health. Nutrients, 10(7), 921. https://doi.org/10.3390/NU10070921
Beck, K. L., Thomson, J. S., Swift, R. J., & Hurst, P. R. von. (2015). Role of nutrition in performance enhancement and postexercise recovery. Open Access Journal of Sports Medicine, 6, 259. https://doi.org/10.2147/OAJSM.S33605
Behrens, M., Gube, M., Chaabene, H., Prieske, O., Zenon, A., Broscheid, K. C., Schega, L., Husmann, F., & Weippert, M. (2022). Fatigue and Human Performance: An Updated Framework. Sports Medicine (Auckland, N.Z.), 53(1), 7. https://doi.org/10.1007/S40279-022-01748-2
Botchlett, R., Lawler, J., & Wu, G. (2019). L-Arginine and l-citrulline in sports nutrition and health. In Nutrition and enhanced sports performance (pp. 645–652). Academic Press.
Chappell, A. J., Allwood, D. M., Johns, R., Brown, S., Sultana, K., Anand, A., & Simper, T. (2018). Citrulline malate supplementation does not improve German Volume Training performance or reduce muscle soreness in moderately trained males and females. Journal of the International Society of Sports Nutrition, 15(1), 42. https://doi.org/10.1186/S12970-018-0245-8
Cheung, K., Hume, P. A., & Maxwell, L. (2003). Delayed onset muscle soreness : treatment strategies and performance factors. Sports Medicine (Auckland, N.Z.), 33(2), 145–164. https://doi.org/10.2165/00007256-200333020-00005
Collins, J. K., Wu, G., Perkins-Veazie, P., Spears, K., Claypool, P. L., Baker, R. A., & Clevidence, B. A. (2007). Watermelon consumption increases plasma arginine concentrations in adults. Nutrition (Burbank, Los Angeles County, Calif.), 23(3), 261–266. https://doi.org/10.1016/J.NUT.2007.01.005
da Silva, D. K., Jacinto, J. L., de Andrade, W. B., Roveratti, M. C., Estoche, J. M., Balvedi, M. C. W., de Oliveira, D. B., da Silva, R. A., & Aguiar, A. F. (2017). Citrulline malate does not improve muscle recovery after resistance exercise in untrained young adult men. Nutrients, 9(10). https://doi.org/10.3390/NU9101132,
Figueroa, A., Wong, A., Hooshmand, S., & Sanchez-Gonzalez, M. A. (2013). Effects of watermelon supplementation on arterial stiffness and wave reflection amplitude in postmenopausal women. Menopause, 20(5), 573–577. https://doi.org/10.1097/gme.0b013e3182733794
Flores-Ramírez, A. G., Tovar-Villegas, V. I., Maharaj, A., Garay-Sevilla, M. E., & Figueroa, A. (2021). Effects of L-Citrulline Supplementation and Aerobic Training on Vascular Function in Individuals with Obesity across the Lifespan. Nutrients, 13(9), 2991. https://doi.org/10.3390/NU13092991
Forbes, S. C., Candow, D. G., Neto, J. H. F., Kennedy, M. D., Forbes, J. L., Machado, M., Bustillo, E., Gomez-Lopez, J., Zapata, A., & Antonio, J. (2023). Creatine supplementation and endurance performance: surges and sprints to win the race. Journal of the International Society of Sports Nutrition, 20(1), 2204071. https://doi.org/10.1080/15502783.2023.2204071
Gentilin, A., Zanini, P., Cevese, A., Schena, F., & Tarperi, C. (2022). Ergogenic effects of citrulline supplementation on exercise performance and physiological indexes of exercise performance during cycling tests: A review. Science & Sports, 37(8), 665–674. https://doi.org/10.1016/J.SCISPO.2021.12.011
Gonzalez, A. M. ;, Townsend, J. R. ;, Pinzone, A. G. ;, Hoffman, J. R., Eckerson, J. M., Gonzalez, A. M., Townsend, J. R., Pinzone, A. G., & Hoffman, J. R. (2023). Supplementation with Nitric Oxide Precursors for Strength Performance: A Review of the Current Literature. Nutrients, 15(3), 660. https://doi.org/10.3390/NU15030660
Gonzalez, A. M., & Trexler, E. T. (2020). Effects of Citrulline Supplementation on Exercise Performance in Humans: A Review of the Current Literature. Journal of Strength and Conditioning Research, 34(5), 1480–1495. https://doi.org/10.1519/JSC.0000000000003426
Gough, L. A., Sparks, S. A., McNaughton, L. R., Higgins, M. F., Newbury, J. W., Trexler, E., Faghy, M. A., & Bridge, C. A. (2021b). A critical review of citrulline malate supplementation and exercise performance. European Journal of Applied Physiology, 121(12), 3283–3295. https://doi.org/10.1007/S00421-021-04774-6/TABLES/1
Grala, A., Candellório, É., Sperandio, P., Maldonado, E., Dos Anjos, B., Jacinto, J., Casonatto, J., & Aguiar, A. (2021). Effects of Citrulline Malate Supplementation on Aerobic and Muscular Endurance in Young Adults Men. Journal of Health Sciences, 23(1), 72–78. https://doi.org/10.17921/2447-8938.2021V23N1P72-78
Harnden, C. S., Agu, J. O. S. E. P. H., & Gascoyne, T. O. M. (2023). Effects of citrulline on endurance performance in young healthy adults: a systematic review and meta-analysis. Journal of the International Society of Sports Nutrition, 20(1), 2209056. https://doi.org/10.1080/15502783.2023.2209056
Hasanah, U., & Fitranti, D. Y. (2015). Perbedaan Nilai Kelelahan Anaerobik Atlet Sepakbola Yang Diberikan Buah Semangka Merah Dan Tidak Diberikan Buah Semangka Merah (Citrullus lanatus). Journal of Nutrition College, 4(2), 147–153. https://doi.org/10.14710/JNC.V4I2.10059
Hody, S., Croisier, J. L., Bury, T., Rogister, B., & Leprince, P. (2019a). Eccentric Muscle Contractions: Risks and Benefits. Frontiers in Physiology, 10(MAY), 536. https://doi.org/10.3389/FPHYS.2019.00536
Imbard, A., Bouchereau, J., Arnoux, J. B., Brassier, A., Schiff, M., Bérat, C. M., Pontoizeau, C., Benoist, J. F., Josse, C., Montestruc, F., & de Lonlay, P. (2023). Citrulline in the management of patients with urea cycle disorders. Orphanet Journal of Rare Diseases, 18(1), 207. https://doi.org/10.1186/S13023-023-02800-8
Kafrawi, F. R., Nurhasan, Wahjuni, E. S., Rusdiawan, A., Bekti, A. P., & Ayubi, N. (2024). Sports Massage Has The Potential To Reduce Ischemic Muscle Pain And Increase Range Of Motion After Exercise. Polish Journal of Physiotherapy, 24(1), 60–65. https://doi.org/doi.org/10.56984/8ZG2EF85A3
Kaore, S. N., Amane, H. S., & Kaore, N. M. (2013). Citrulline: pharmacological perspectives and its role as an emerging biomarker in future. Fundamental & Clinical Pharmacology, 27(1), 35–50. https://doi.org/10.1111/J.1472-8206.2012.01059.X
Kiani, A. K., Bonetti, G., Medori, M. C., Caruso, P., Manganotti, P., Fioretti, F., Nodari, S., Connelly, S. T., & Bertelli, M. (2022). Dietary supplements for improving nitric-oxide synthesis. Journal of Preventive Medicine and Hygiene, 63(2 Suppl 3), E239. https://doi.org/10.15167/2421-4248/JPMH2022.63.2S3.2766
Kim, J., & Lee, J. (2014). A review of nutritional intervention on delayed onset muscle soreness. Part I. Journal of Exercise Rehabilitation, 10(6), 349. https://doi.org/10.12965/JER.140179
Kiyici, F., Eroğlu, H., Kishali, N. F., & Burmaoglu, G. (2017). The Effect of Citrulline/Malate on Blood Lactate Levels in Intensive Exercise. Biochemical Genetics, 55(5–6), 387–394. https://doi.org/10.1007/S10528-017-9807-8
Kreider, R. B., & Stout, J. R. (2021). Creatine in Health and Disease. Nutrients 2021, Vol. 13, Page 447, 13(2), 447. https://doi.org/10.3390/NU13020447
Kusuma, D. A. (2018). Evaluasi Kelelahan pada Latihan Olahraga. Indonesia Performance Journal, 2(1), 55–60.
Lau, W. Y., Blazevich, A. J., Newton, M. J., Xuan Wu, S. S., & Nosaka, K. (2015). Assessment of Muscle Pain Induced by Elbow-Flexor Eccentric Exercise. Journal of Athletic Training, 50(11), 1140. https://doi.org/10.4085/1062-6050-50.11.05
Nyawose, S., Naidoo, R., Naumovski, N., & McKune, A. J. (2022). The Effects of Consuming Amino Acids L-Arginine, L-Citrulline (and Their Combination) as a Beverage or Powder, on Athletic and Physical Performance: A Systematic Review. Beverages 2022, Vol. 8, Page 48, 8(3), 48. https://doi.org/10.3390/BEVERAGES8030048
Paradisis, G. P., Zacharogiannis, E., Mandila, D., Smirtiotou, A., Argeitaki, P., & Cooke, C. B. (2014). Multi-Stage 20-m Shuttle Run Fitness Test, Maximal Oxygen Uptake and Velocity at Maximal Oxygen Uptake. Journal of Human Kinetics, 41(1), 81. https://doi.org/10.2478/HUKIN-2014-0035
Pérez-Guisado, J., & Jakeman, P. M. (2010a). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. Journal of Strength and Conditioning Research, 24(5), 1215–1222. https://doi.org/10.1519/JSC.0B013E3181CB28E0
Premont, R. T., Reynolds, J. D., Zhang, R., & Stamler, J. S. (2020). Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle. Circulation Research, 126(1), 129–158. https://doi.org/10.1161/CIRCRESAHA.119.315626/ASSET/C4CEB691-E74A-43A0-B9C9-BA3A794AFE8C/ASSETS/IMAGES/LARGE/129FIG07.JPG
Rabier, D., & Kamoun, P. (1995). Metabolism of citrulline in man. Amino Acids 1995 9:4, 9(4), 299–316. https://doi.org/10.1007/BF00807268
Rhim, H. C., Kim, S. J., Park, J., & Jang, K. M. (2020). Effect of citrulline on post-exercise rating of perceived exertion, muscle soreness, and blood lactate levels: A systematic review and meta-analysis. Journal of Sport and Health Science, 9(6), 553–561. https://doi.org/10.1016/J.JSHS.2020.02.003
Rizal, M., & Segalita, C. (2018). Peran Asam Amino Sitrulin dalam Meningkatkan Performa Olahraga Pada Atlet. Amerta Nutrition, 2(4), 299–306. https://doi.org/10.2473/amnt.v2i4.2018.299-306
Rusdiawan, A., & Habibi, A. I. (2020). Efek pemberian jus semangka kuning terhadap tekanan darah, kadar asam laktat, dan daya tahan anaerobik setelah aktivitas anaerobic. Jurnal SPORTIF : Jurnal Penelitian Pembelajaran. https://doi.org/10.29407/JS_UNPGRI.VI.13712
Rusdiawan, A., Mar, A., & Prihatiningsih, S. (2020). The Changes in pH Levels , Blood Lactic Acid and Fatigue Index to Anaerobic Exercise on Athlete After. Malaysian Journal of Medicine and Health Sciences, 16(10), 50–56.
Setiawan, M. I., & Widyastuti, N. (2016). Pengaruh Pemberian Jus Semangka Kuning (Citrulus Lanatus) Terhadap Konsumsi Oksigen Maksimal (Vo2Max) Pada Atlet Sepak Bola. Journal of Nutrition College, 5(2), 64–70. https://ejournal3.undip.ac.id/index.php/jnc/article/view/16361/15785
Setiowati, A., & Sumartiningsih, S. (2020). Efek Akut Pemberian Asam Amino Citrulin Alami Terhadap Kekuatan Otot. Media Ilmu Keolahragaan Indonesia, 10(2), 39–45. https://doi.org/10.15294/miki.v10i2.27120
Stuehr, D. J. (2004). Enzymes of the L-arginine to nitric oxide pathway. Journal of Nutrition, 134(10 SUPPL.), 2748S-2751S. https://doi.org/10.1093/jn/134.10.2748s
Sun, M., Jiao, H., Wang, X., Li, H., Zhou, Y., Zhao, J., & Lin, H. (2022). The regulating pathway of creatine on muscular protein metabolism depends on the energy state. American Journal of Physiology - Cell Physiology, 322(5), C1022–C1035. https://doi.org/10.1152/AJPCELL.00447.2021/ASSET/IMAGES/LARGE/AJPCELL.00447.2021_F009.JPEG
Suzuki, I., Sakuraba, K., Horiike, T., Kishi, T., Yabe, J., Suzuki, T., Morita, M., Nishimura, A., & Suzuki, Y. (2019). A combination of oral l-citrulline and l-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial. European Journal of Applied Physiology, 119(5), 1075–1084. https://doi.org/10.1007/S00421-019-04097-7/FIGURES/4
Suzuki, T., Morita, M., Kobayashi, Y., & Kamimura, A. (2016). Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study. Journal of the International Society of Sports Nutrition, 13(1), 2–9. https://doi.org/10.1186/s12970-016-0117-z
Theodorou, A. A., Zinelis, P. T., Malliou, V. J., Chatzinikolaou, P. N., Margaritelis, N. V., Mandalidis, D., Geladas, N. D., & Paschalis, V. (2021). Acute L-Citrulline Supplementation Increases Nitric Oxide Bioavailability but Not Inspiratory Muscle Oxygenation and Respiratory Performance. Nutrients, 13(10), 3311. https://doi.org/10.3390/NU13103311
Tomalka, A. (2023). Eccentric muscle contractions: from single muscle fibre to whole muscle mechanics. Pflugers Archiv, 475(4), 421. https://doi.org/10.1007/S00424-023-02794-Z
Valaei, K., Mehrabani, J., & Wong, A. (2021). Effects of L-citrulline supplementation on nitric oxide and antioxidant markers after high-intensity interval exercise in young men: a randomized controlled trial. The British Journal of Nutrition, 127(9), 1303–1312. https://doi.org/10.1017/S0007114521002178
Viribay, A., Fernández-Landa, J., Castañeda-Babarro, A., Collado, P. S., Fernández-Lázaro, D., & Mielgo-Ayuso, J. (2022). Effects of Citrulline Supplementation on Different Aerobic Exercise Performance Outcomes: A Systematic Review and Meta-Analysis. Nutrients, 14(17), 3479. https://doi.org/10.3390/NU14173479
Vulturar, R., Jurjiu, B., Damian, M., Bojan, A., Pintilie, S. R., Jurca, C., Chis, A., & Grad, S. (2021). Creatine supplementation and muscles: From metabolism to medical practice. Romanian Journal of Medical Practice, 16(3), 317–321. https://doi.org/10.37897/RJMP.2021.3.4
Wax, B., Kavazis, A. N., Weldon, K., & Sperlak, J. (2015). Effects of supplemental citrulline malate ingestion during repeated bouts of lower-body exercise in advanced weightlifters. Journal of Strength and Conditioning Research, 29(3), 786–792. https://doi.org/10.1519/JSC.0000000000000670
Wilke, J., & Behringer, M. (2021). Is “Delayed Onset Muscle Soreness” a False Friend? The Potential Implication of the Fascial Connective Tissue in Post-Exercise Discomfort. International Journal of Molecular Sciences, 22(17), 9482. https://doi.org/10.3390/IJMS22179482
Wyss, M., & Kaddurah-Daouk, R. (2000). Creatine and creatinine metabolism. Physiological Reviews, 80(3), 1107–1213. https://doi.org/10.1152/PHYSREV.2000.80.3.1107/ASSET/IMAGES/LARGE/9J0300087020.JPEG
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Direitos de Autor (c) 2025 Sapto Wibowo, Himawan Wismanadi, Afif Rusdiawan, Oce Wiriawan, Cemal Özman, Muhammad Labib Siena Ar Rasyid, Kunjung Ashadi, Luthfie Lufthansa, Nur Khozanah Ilmah, Taufiq Hidayat
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