Effectiveness of blood flow restriction in lower limb tendons: a systematic review

Authors

DOI:

https://doi.org/10.47197/retos.v72.99681

Keywords:

(blood flow restriction training), kaatsu, lower extemity tendinopathy, tendon

Abstract

Introduction: Lower limb tendinopathy is a common condition that leads to pain and functional limitations, particularly among physically active individuals. While high-load training promotes tendon adaptation, its early use in rehabilitation may aggravate symptoms. Blood flow restriction (BFR) training has emerged as a promising low-load alternative.

Objective: To evaluate the effectiveness of BFR training on the structural and functional properties of lower limb tendons through a systematic review of controlled clinical trials.

Methodology: Following PRISMA guidelines, five databases were searched up to March 2025. Five controlled clinical trials involving 232 participants with and without tendinopathy were included. Methodological quality was assessed using the Cochrane RoB 2 tool and the PEDro scale. Interventions involved low-load resistance exercise (20–35% 1RM) combined with BFR, compared against high-load training or no intervention.

Results: Studies reported significant improvements in tendon thickness, cross-sectional area, and muscle strength with low-load BFR training. These outcomes were generally comparable to high-load protocols. However, acute responses varied across studies, with inconsistent changes in tendon thickness observed post-exercise.

Discussion: BFR training appears to promote structural and functional improvements without requiring high loads, although more consistent studies are needed to standardize protocols and outcomes.

Conclusion: BFR is a promising strategy for managing lower limb tendinopathies, especially when high-load exercise is contraindicated. More robust studies are needed to standardize protocols and explore long-term benefits in both clinical and athletic populations.

Author Biographies

  • Waldo Osorio-Torres, Universidad San Sebastián, Escuela de Kinesiología, Facultad de Ciencias de la Rehabilitación. Lientur 1457, Concepción, Chile.

    Kinesiólogo titulado de la Universidad San Sebastián, con formación de posgrado que incluye un Magíster en Ciencias de la Salud y Deporte (Universidad Finis Terrae) y un Magíster en Rehabilitación Cardiometabólica (Universidad San Sebastián). Ha complementado su formación con diplomados en Rehabilitación de Extremidad Inferior (PUC) y en Simulación Clínica (USS), además de diversas certificaciones en técnicas avanzadas como Kinesiotaping neuromuscular, punción seca, ondas de choque, FAKTR y manejo de tendinopatías de extremidad inferior. Se desempeña como docente de pregrado en el área musculoesquelética y como guía clínico en el Centro Kinésico de la Universidad San Sebastián.

  • Gonzalo Arias-Álvarez, Universidad San Sebastián, Escuela de Kinesiología, Facultad de Ciencias de la Rehabilitación. Lientur 1457, Concepción, Chile.

    Soy kinesiólogo y quiropráctico con una formación orientada al abordaje musculoesquelético desde una perspectiva integral. Me titulé como Licenciado en Kinesiología en la Universidad San Sebastián y como Licenciado en Quiropraxia en la Universidad Central de Chile. Posteriormente, realicé un Máster en Terapia Manual Ortopédica en la Universidad de Zaragoza y un Magíster en Educación Superior en la Universidad Católica de la Santísima Concepción. Además, me especialicé en Kinesiología Musculoesquelética a través de DENAKE y he complementado mi formación con diplomados en Terapia Manual (Universidad de Chile) y Simulación Clínica (USS), junto con certificaciones en técnicas como Motion Palpation (MPI), RPG, McConnell Therapy y punción seca. Actualmente, me desempeño como docente en la línea musculoesquelética tanto a nivel de pregrado como de postgrado, y como guía clínico en el Centro Kinésico de la Universidad San Sebastián. En paralelo, curso estudios de doctorado en Biomecánica y Bioingeniería Aplicada a la Salud en la Universidad de Alcalá de Henares, España.

References

Bahamondes-Avila, C., Curilem Gatica, C., Bustos Medina, L., Berral de la Rosa, F., & Salazar, L. A. (2024). Abordaje fisioterapéutico del ejercicio con restricción parcial del flujo sanguíneo: Revisión narrativa [Physiotherapeutic approach to exercise with partial restriction of blood flow: Narrative review]. Retos, 58, 617–632. https://doi.org/10.47197/retos.v58.99878

Barber-Westin, S., & Noyes, F. R. (2019). Blood Flow-Restricted Training for Lower Extremity Muscle Weakness due to Knee Pathology: A Systematic Review. Sports Health, 11(1), 69-83. https://doi.org/10.1177/1941738118811337

Beyer, R., Kongsgaard, M., Hougs Kjær, B., Øhlenschlæger, T., Kjær, M., & Magnusson, S. P. (2015). Heavy Slow Resistance Versus Eccentric Training as Treatment for Achilles Tendinopathy: A Randomized Controlled Trial. The American Journal of Sports Medicine, 43(7), 1704-1711. https://doi.org/10.1177/0363546515584760

Bjørnsen, T., Wernbom, M., Kirketeig, A., Paulsen, G., Samnøy, L., Bækken, L., Cameron-Smith, D., Berntsen, S., & Raastad, T. (2019). Type 1 Muscle Fiber Hypertrophy after Blood Flow-restricted Training in Powerlifters. Medicine and Science in Sports and Exercise, 51(2), 288-298. https://doi.org/10.1249/MSS.0000000000001775

Bohm, S., Mersmann, F., & Arampatzis, A. (2015). Human tendon adaptation in response to mechanical loading: A systematic review and meta-analysis of exercise intervention studies on healthy adults. Sports Medicine - Open, 1(1), 7. https://doi.org/10.1186/s40798-015-0009-9

Burton, I. (2023). Blood Flow Restriction Training for Tendinopathy Rehabilitation: A Potential Alternative to Traditional Heavy-Load Resistance Training. Rheumato, 3(1), 23-50. https://doi.org/10.3390/rheumato3010003

Burton, I., & McCormack, A. (2022). Blood Flow Restriction Resistance Training in Tendon Rehabilitation: A Scoping Review on Intervention Parameters, Physiological Effects, and Outcomes. Frontiers in Sports and Active Living, 4, 879860. https://doi.org/10.3389/fspor.2022.879860

Centner, C., Jerger, S., Lauber, B., Seynnes, O., Friedrich, T., Lolli, D., Gollhofer, A., & König, D. (2022). Low-Load Blood Flow Restriction and High-Load Resistance Training Induce Comparable Changes in Patellar Tendon Properties. Medicine and Science in Sports and Exercise, 54(4), 582-589. https://doi.org/10.1249/MSS.0000000000002824

Centner, C., Jerger, S., Lauber, B., Seynnes, O., Friedrich, T., Lolli, D., Gollhofer, A., & König, D. (2023). Similar patterns of tendon regional hypertrophy after low-load blood flow restriction and high-load resistance training. Scandinavian Journal of Medicine & Science in Sports, 33(6), 848-856. https://doi.org/10.1111/sms.14321

Centner, C., Lauber, B., Seynnes, O. R., Jerger, S., Sohnius, T., Gollhofer, A., & König, D. (2019). Low-load blood flow restriction training induces similar morphological and mechanical Achilles tendon adaptations compared with high-load resistance training. Journal of Applied Physiology (Bethesda, Md. : 1985), 127(6), 1660-1667. https://doi.org/10.1152/japplphysiol.00602.2019

Chulvi-Medrano, I., Picón-Martínez, M., Cortell-Tormo, J. M., Tortosa-Martínez, J., Alonso-Aubin, D. A., & Alakhdar, Y. (2020). Different Time Course of Recovery in Achilles Tendon Thickness After Low-Load Resistance Training With and Without Blood Flow Restriction. Journal of Sport Rehabilitation, 30(2), 300-305. https://doi.org/10.1123/jsr.2019-0403

Couppé, C., Svensson, R. B., Silbernagel, K. G., Langberg, H., & Magnusson, S. P. (2015). Eccentric or Concentric Exercises for the Treatment of Tendinopathies? The Journal of Orthopaedic and Sports Physical Therapy, 45(11), 853-863. https://doi.org/10.2519/jospt.2015.5910

Dean, B. J. F., Dakin, S. G., Millar, N. L., & Carr, A. J. (2017). Review: Emerging concepts in the pathogenesis of tendinopathy. The Surgeon, 15(6), 349-354. https://doi.org/10.1016/j.surge.2017.05.005

Domínguez-Gavia, N. I., Candia-Luján, R., Candia-Sosa, K. F., Acosta-Carreño, R. E., & Herrera-Covarrubias, C. I. (2025). Ejercicio excéntrico como protocolo de intervención para la profilaxis y rehabilitación de lesiones en deportistas: Una revisión sistemática. Retos: nuevas tendencias en educación física, deporte y recreación, 63, 144–155. https://doi.org/10.47197/retos.v63.109368

Higgins, J. P. T. & Cochrane Collaboration (Eds.). (2019). Cochrane handbook for systematic reviews of interventions (Second edition). Wiley-Blackwell.

Hopkins, C., Fu, S.-C., Chua, E., Hu, X., Rolf, C., Mattila, V. M., Qin, L., Yung, P. S.-H., & Chan, K.-M. (2016). Critical review on the socio-economic impact of tendinopathy. Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 4, 9-20. https://doi.org/10.1016/j.asmart.2016.01.002

Hughes, L., Grant, I., & Patterson, S. D. (2021). Aerobic exercise with blood flow restriction causes local and systemic hypoalgesia and increases circulating opioid and endocannabinoid levels. Journal of Applied Physiology (Bethesda, Md. : 1985), 131(5), 1460-1468. https://doi.org/10.1152/japplphysiol.00543.2021

Hughes, L., Rosenblatt, B., Haddad, F., Gissane, C., McCarthy, D., Clarke, T., Ferris, G., Dawes, J., Paton, B., & Patterson, S. D. (2019). Comparing the Effectiveness of Blood Flow Restriction and Traditional Heavy Load Resistance Training in the Post-Surgery Rehabilitation of Anterior Cruciate Ligament Reconstruction Patients: A UK National Health Service Randomised Controlled Trial. Sports Medicine (Auckland, N.Z.), 49(11), 1787-1805. https://doi.org/10.1007/s40279-019-01137-2

Karabulut, M., Esparza, B., Dowllah, I. M., & Karabulut, U. (2021). The impact of low-intensity blood flow restriction endurance training on aerobic capacity, hemodynamics, and arterial stiffness. The Journal of Sports Medicine and Physical Fitness, 61(7), 877-884. https://doi.org/10.23736/S0022-4707.20.11526-3

Kongsgaard, M., Qvortrup, K., Larsen, J., Aagaard, P., Doessing, S., Hansen, P., Kjaer, M., & Magnusson, S. P. (2010). Fibril morphology and tendon mechanical properties in patellar tendinopathy: Effects of heavy slow resistance training. The American Journal of Sports Medicine, 38(4), 749-756. https://doi.org/10.1177/0363546509350915

Korakakis, V., Whiteley, R., & Epameinontidis, K. (2018). Blood Flow Restriction induces hypoalgesia in recreationally active adult male anterior knee pain patients allowing therapeutic exercise loading. Physical Therapy in Sport : Official Journal of the Association of Chartered Physiotherapists in Sports Medicine, 32, 235-243. https://doi.org/10.1016/j.ptsp.2018.05.021

Krzysztofik, M., Wilk, M., Wojdała, G., & Gołaś, A. (2019). Maximizing Muscle Hypertrophy: A Systematic Review of Advanced Resistance Training Techniques and Methods. International Journal of Environmental Research and Public Health, 16(24). https://doi.org/10.3390/ijerph16244897

Loenneke, J. P., Thiebaud, R. S., Fahs, C. A., & Rossow, L. M. (2012). Blood flow-restricted resistance exercise: Rapidly affecting the myofibre and the myonuclei. The Journal of Physiology, 590(21), 5271. https://doi.org/10.1113/jphysiol.2012.242859

Lorenz, D. S., Bailey, L., Wilk, K. E., Mangine, R. E., Head, P., Grindstaff, T. L., & Morrison, S. (2021). Blood Flow Restriction Training. Journal of Athletic Training, 56(9), 937-944. https://doi.org/10.4085/418-20

Magnusson, S. P., & Kjaer, M. (2019). The impact of loading, unloading, ageing and injury on the human tendon. The Journal of Physiology, 597(5), 1283-1298. https://doi.org/10.1113/JP275450

Millar, N. L., Murrell, G. A. C., & McInnes, I. B. (2017). Inflammatory mechanisms in tendinopathy – towards translation. Nature Reviews Rheumatology, 13(2), 110-122. https://doi.org/10.1038/nrrheum.2016.213

Millar, N. L., Silbernagel, K. G., Thorborg, K., Kirwan, P. D., Galatz, L. M., Abrams, G. D., Murrell, G. A. C., McInnes, I. B., & Rodeo, S. A. (2021). Tendinopathy. Nature Reviews Disease Primers, 7(1), 1. https://doi.org/10.1038/s41572-020-00234-1

Neto, G. R., Novaes, J. S., Dias, I., Brown, A., Vianna, J., & Cirilo-Sousa, M. S. (2017). Effects of resistance training with blood flow restriction on haemodynamics: A systematic review. Clinical Physiology and Functional Imaging, 37(6), 567-574. https://doi.org/10.1111/cpf.12368

Nitzsche, N., Stäuber, A., Tiede, S., & Schulz, H. (2021). The effectiveness of blood-flow restricted resistance training in the musculoskeletal rehabilitation of patients with lower limb disorders: A systematic review and meta-analysis. Clinical Rehabilitation, 35(9), 1221-1234. https://doi.org/10.1177/02692155211003480

Panza, P., Vieira, J. G., Campos, Y., Novaes, M., Novaes, J., & Vianna, J. M. (2025). Effects of final partial range of motion vs. full range of motion resistance training on muscle adaptations in physically active young men: A within-subject study. Retos, 62, 388–397. https://doi.org/10.47197/retos.v62.109453

Patterson, S. D., Hughes, L., Warmington, S., Burr, J., Scott, B. R., Owens, J., Abe, T., Nielsen, J. L., Libardi, C. A., Laurentino, G., Neto, G. R., Brandner, C., Martin-Hernandez, J., & Loenneke, J. (2019). Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety. Frontiers in Physiology, 10, 533. https://doi.org/10.3389/fphys.2019.00533

Pearson, S. J., & Hussain, S. R. (2014). A review on the mechanisms of blood-flow restriction resistance training-induced muscle hypertrophy. Sports Medicine, 45(2), 187–200. https://doi.org/10.1007/s40279-014-0264-9

Picón-Martínez, M., Chulvi-Medrano, I., Cortell-Tormo, J. M., Alonso-Aubin, D. A., Alakhdar, Y., & Laurentino, G. (2021). Acute Effects of Resistance Training with Blood Flow Restriction on Achilles Tendon Thickness. Journal of Human Kinetics, 78, 101-109. https://doi.org/10.2478/hukin-2021-0032

Silva, J. C. G., Aniceto, R. R., Oliota-Ribeiro, L. S., Neto, G. R., Leandro, L. S., & Cirilo-Sousa, M. S. (2018). Mood Effects of Blood Flow Restriction Resistance Exercise Among Basketball Players. Perceptual and Motor Skills, 125(4), 788-801. https://doi.org/10.1177/0031512518776847

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Published

16-09-2025

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Section

Theoretical systematic reviews and/or meta-analysis

How to Cite

Osorio-Torres, W., Venegas de la Paz, M., Vargas-Foitzick, R., & Arias-Álvarez, G. (2025). Effectiveness of blood flow restriction in lower limb tendons: a systematic review. Retos, 72, 654-663. https://doi.org/10.47197/retos.v72.99681